Linear Acanthosis Nigricans
نویسنده
چکیده
Acathosis nigricans (AN) typically presents as symmetric, brownish-black, velvety, hypertrophic, verrucous, and at times papillomatous plaques most commonly involving the flexural sites [1]. It is a cutaneous marker, most frequently of insulin resistance and less frequently of malignancy [2]. AN has been classified into 8 types: benign, obesity-related, syndromic, malignant, unilateral, acral, drug-induced, and mixed AN which is a combination of one or more of the above [1]. Nevoid AN is a variant characterized by unilateral distribution of morphologically and histopathologically diagnosable AN without any other accompaniment of common AN. We report a case of nevoid AN which was linearly distributed in the leg.
منابع مشابه
Crouzon syndrome in association with acanthosis nigricans
Crouzon syndrome is a rare inherited autosomal dominant syndrome characterized by craniosynostosis, midface hypoplasia. Acanthosis nigricans may be associated with Crouzon syndrome, but it differs from the classic crouzon syndrome. This is a report of a 30-year-old-woman who presented acanthosis nigricans coexist with crouzon syndrome.
متن کاملComparison of Insulin resistance in obese women with and without Acanthosis Nigricans
Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of AN. In this study insulin resistance was compared in obese women with and without AN.</sp...
متن کاملDermoscopic Features of Hyperpigmented Dots in Crista Cutis in Two Siblings in a Japanese Family with Inherited Acanthosis Nigricans
Acanthosis nigricans is characterized by papillomatous brownish lesions mainly in the intertriginous areas. We used dermoscopy to examine such lesions in a family with acanthosis nigricans. The dermoscopic images showed an aberrant skin structure of linear crista cutis and sulcus cutis, and hyperpigmented dots in crista cutis. The hyperpigmented dots, which could not be seen with the naked eyes...
متن کاملFamilial acanthosis nigricans due to K650T FGFR3 mutation.
BACKGROUND Acanthosis nigricans is a feature of several syndromes caused by activating mutations of the fibroblast growth factor receptor 3 gene (FGFR3), including Crouzon syndrome with acanthosis nigricans, thanatophoric dysplasia, and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN syndrome). OBSERVATIONS We describe a healthy 4-year-old African American girl...
متن کاملCutaneous features of Crouzon syndrome with acanthosis nigricans.
IMPORTANCE Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described. OBSERVATIONS We report 6 cases and summarize the existing literature with regard to the cutaneous manifestat...
متن کاملHypochondroplasia, Acanthosis Nigricans, and Insulin Resistance in a Child with FGFR3 Mutation: Is It Just an Association?
FGFR3 mutations cause wide spectrum of disorders ranging from skeletal dysplasias (hypochondroplasia, achondroplasia, and thanatophoric dysplasia), benign skin tumors (epidermal nevi, seborrhaeic keratosis, and acanthosis nigricans), and epithelial malignancies (multiple myeloma and prostate and bladder carcinoma). Hypochondroplasia is the most common type of short-limb dwarfism in children res...
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